Intrauterine Growth Restriction Induces Adulthood Chronic Metabolic Disorder in Cardiac and Skeletal Muscles.

ABSTRACT:

Objective

Although population-based studies of intrauterine growth restriction (IUGR) demonstrated a series of postnatal complications, several studies identified that IUGR could definitely cause dysfunction of metabolism of cardiac and skeletal muscles in the perinatal period and early life. However, it is still unknown if such metabolic alternation would remain for long term or not, and whether normal protein diet administration postnatally would protect the IUGR offsprings from a "catch-up growth" and be able to reverse the premature metabolic remodeling.

Materials and methods

We established an IUGR rat model with pregnant rats and a low-protein diet, and the developmental phenotypes had been carefully recorded. The cardiac and skeletal muscles had been collected to under

SUBMITTER: Li P 

PROVIDER: S-EPMC9354130 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature