Recent advances in conventional and unconventional vesicular secretion pathways in the tumor microenvironment.

ABSTRACT: All cells in the changing tumor microenvironment (TME) need a class of checkpoints to regulate the balance among exocytosis, endocytosis, recycling and degradation. The vesicular trafficking and secretion pathways regulated by the small Rab GTPases and their effectors convey cell growth and migration signals and function as meditators of intercellular communication and molecular transfer. Recent advances suggest that Rab proteins govern conventional and unconventional vesicular secretion pathways by trafficking widely diverse cargoes and substrates in remodeling TME. The mechanisms underlying the regulation of conventional and unconventional vesicular secretion pathways, their action modes and impacts on the cancer and stromal cells have been the focus of much attention for the past two de

SUBMITTER: Kuo IY 

PROVIDER: S-EPMC9354273 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature