Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial.

ABSTRACT:

Purpose

Dexmedetomidine has been proposed as an additive to local anesthetics to prolong peripheral nerve block duration; however, perineural dexmedetomidine has been associated with an increased risk of bradycardia and hypotension This randomized controlled study investigated the effects of low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia.

Methods

Fifty-five patients who had undergone elective upper extremity surgery were randomized to receive an ultrasound-guided supraclavicular brachial plexus block with 20 mL 0.5% ropivacaine with or without 30 μg dexmedetomidine. The primary outcome was the duration of analgesia. Secondary outcomes included the onset time and duration of the motor and sensory blocks, incidence of hypotension and bradycardia,

SUBMITTER: Liu W 

PROVIDER: S-EPMC9354301 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature