In-silico design of an immunoinformatics based multi-epitope vaccine against Leishmania donovani.

ABSTRACT:

Background

Visceral Leishmaniasis (VL) is a fatal vector-borne parasitic disorder occurring mainly in tropical and subtropical regions. VL falls under the category of neglected tropical diseases with growing drug resistance and lacking a licensed vaccine. Conventional vaccine synthesis techniques are often very laborious and challenging. With the advancement of bioinformatics and its application in immunology, it is now more convenient to design multi-epitope vaccines comprising predicted immuno-dominant epitopes of multiple antigenic proteins. We have chosen four antigenic proteins of Leishmania donovani and identified their T-cell and B-cell epitopes, utilizing those for in-silico chimeric vaccine designing. The various physicochemical characteristics of the vaccine have been exp

SUBMITTER: Saha S 

PROVIDER: S-EPMC9354309 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature