The clinicopathological and prognostic significances of IGF-1R and Livin expression in patients with colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common cancer worldwide. However, limited effective biomarkers are associated with the tumorigenesis and prognosis of CRC.

Methods

The present study identified potential signatures from The Cancer Genome Atlas (TCGA) database and further validated the identified biomarkers in CRC tissues by immunohistochemistry (IHC).

Results

The expression of insulin-like growth factor 1 receptor (IGF-1R) and Livin gene was significantly upregulated in CRC samples compared to the adjacent normal samples in the TCGA dataset. IHC indicated that IGF-1R and Livin protein levels are increased in CRC and adenoma tissues compared to normal tissues. Notably, the IGF-1R protein levels differed significantly between adenoma and CRC. The elev

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC9354317 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature