The expression and clinical significance of miR-30b-3p and miR-125b-1-3p in patients with periodontitis.

ABSTRACT:

Objective

Periodontitis is a chronic inflammatory infectious disease caused by the deposition of dental plaque on the tooth surface, leading to adverse systemic consequences. Accumulating evidence shows that dysregulated microRNAs (miRNAs) are associated with the disease severity of periodontitis. Herein, we report two novel miRNAs, miR-30b-3p and miR-125b-1-3p, in the context of periodontitis and their relationships with disease severity of periodontitis.

Methods

The miRNA profiles of gingival crevicular fluid (GCF) samples were used to screen differentially expressed miRNAs (DEmiRNAs) between periodontitis patients and periodontally healthy individuals. Clinical human GCF samples were collected from 80 patients diagnosed with periodontitis (PD +) for the first time and 100

SUBMITTER: Zhu J 

PROVIDER: S-EPMC9354350 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature