Role of TRPC6 in periodontal tissue reconstruction mediated by appropriate stress.

ABSTRACT:

Introduction

The basis of orthodontic tooth movement (OTM) is the reconstruction of periodontal tissue under stress. Increasing the speed of OTM has always been the focus of attention.

Objectives

Periodontal ligament stem cells (PDLSCs) are direct effector cells of mechanical force, but the mechanism by which PDLSCs sense mechanical stimuli is unclear.

Methods

Human PDLSCs (hPDLSCs) were analyzed in the presence or absence of force loading with the Flexcell loading system in vitro. Then, periodontal tissues were analyzed after mechanical stimulation in vivo. In addition, cells in a confined microenvironment were analyzed to observe changes in the cytoskeleton and migration. Finally, TRPC6^-/- mice were used to further verify the effect of TRPC6. After force

SUBMITTER: Wang L 

PROVIDER: S-EPMC9354362 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature