Development of multivariable prediction models for institutionalization and mortality in the full spectrum of Alzheimer's disease.

ABSTRACT:

Background

Patients and caregivers express a desire for accurate prognostic information about time to institutionalization and mortality. Previous studies predicting institutionalization and mortality focused on the dementia stage. However, Alzheimer's disease (AD) is characterized by a long pre-dementia stage. Therefore, we developed prediction models to predict institutionalization and mortality along the AD continuum of cognitively normal to dementia.

Methods

This study included SCD/MCI patients (subjective cognitive decline (SCD) or mild cognitive impairment (MCI)) and patients with AD dementia from the Amsterdam Dementia Cohort. We developed internally and externally validated prediction models with biomarkers and without biomarkers, stratified by dementia status. Deter

SUBMITTER: Mank A 

PROVIDER: S-EPMC9354423 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature