Trimethylamine N-oxide and its precursors in relation to blood pressure: A mendelian randomization study.

ABSTRACT:

Objective

Previous studies have demonstrated that trimethylamine N-oxide (TMAO) and its precursors, including choline, betaine, and carnitine, are closely associated with blood pressure (BP) changes. Nevertheless, with the limitation of reverse causality and confounder in observational studies, such a relationship remains unclear. We aimed to assess the causal relationship of TMAO and its precursors with BP by the Mendelian Randomization (MR) approach.

Method

In this study, two-sample MR was used to reveal the causal effect of TMAO and its precursors on BP. Pooled data of TMAO and its precursors was from genome-wide association studies (GWAS) which includes summary data of human metabolome in 2,076 European participants from Framingham Heart Study. Summary-level data for BP

SUBMITTER: Wang H 

PROVIDER: S-EPMC9354484 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature