Development and therapeutic manipulation of the head and neck cancer tumor environment to improve clinical outcomes.

ABSTRACT: The clinical response to cancer therapies involves the complex interplay between the systemic, tumoral, and stromal immune response as well as the direct impact of treatments on cancer cells. Each individual's immunological and cancer histories are different, and their carcinogen exposures may differ. This means that even though two patients with oral tumors may carry an identical mutation in TP53, they are likely to have different pre-existing immune responses to their tumors. These differences may arise due to their distinct accessory mutations, genetic backgrounds, and may relate to clinical factors including previous chemotherapy exposure and concurrent medical comorbidities. In isolation, their cancer cells may respond similarly to cancer therapy, but due to their baseline variability

SUBMITTER: Duhen T 

PROVIDER: S-EPMC9354490 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature