The interaction between the soluble programmed death ligand-1 (sPD-L1) and PD-1⁺ regulator B cells mediates immunosuppression in triple-negative breast cancer.

ABSTRACT: Accumulating evidence suggests that regulatory B cells (Bregs) play important roles in inhibiting the immune response in tumors. Programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) are important molecules that maintain the balance of the immune response and immune tolerance. This study aims to evaluate the soluble form of PD-L1 and its function in inducing the differentiation of B lymphocytes, investigate the relationship between soluble PD-L1 (sPD-L1) and B-cell subsets, and explore the antitumor activity of T lymphocytes after PD-L1 blockade in coculture systems. In an effort to explore the role of sPD-L1 in human breast cancer etiology, we examined the levels of sPD-L1 and interleukin-10 (IL-10) in the serum of breast tumor patients and the proportions of B cells, PD-1⁺

SUBMITTER: Li X 

PROVIDER: S-EPMC9354578 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature