Initial Decline (Dip) in Estimated Glomerular Filtration Rate After Initiation of Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction: Insights From DAPA-HF.

ABSTRACT:

Background

In a post hoc analysis, the frequency of occurrence of an early decline (dip) in estimated glomerular filtration rate (eGFR) after initiation of dapagliflozin and its association with outcomes were evaluated in patients with heart failure and reduced ejection fraction randomized in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial.

Methods

Patients with heart failure with reduced ejection fraction with or without type 2 diabetes and an eGFR ≥30 mL·min^-1·1.73 m^-2 were randomized to placebo or dapagliflozin 10 mg daily. The primary outcome was the composite of worsening heart failure or cardiovascular death. The extent of the dip in eGFR between baseline and 2 weeks, patient characteristics associated with a >10% decli

SUBMITTER: Adamson C 

PROVIDER: S-EPMC9354593 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature