Identification and characterization of stem cell secretome-based recombinant proteins for wound healing applications.

ABSTRACT: Stem cells have been introduced as a promising therapy for acute and chronic wounds, including burn injuries. The effects of stem cell-based wound therapies are believed to result from the secreted bioactive molecules produced by stem cells. Therefore, treatments using stem cell-derived conditioned medium (CM) (referred to as secretome) have been proposed as an alternative option for wound care. However, safety and regulatory concerns exist due to the uncharacterized biochemical content and variability across different batches of CM samples. This study presents an alternative treatment strategy to mitigate these concerns by using fully characterized recombinant proteins identified by the CM analysis to promote pro-regenerative healing. This study analyzed the secretome profile generated fr

SUBMITTER: Kim JH 

PROVIDER: S-EPMC9354600 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature