Dataset Information

Clinical trials for chimeric antigen receptor T-cell therapy: lessons learned and future directions.

ABSTRACT:

Purpose of review

The purpose of this review is to summarize the status and utilization of chimeric antigen receptor T-cell (CAR-T) therapy based on the most recent clinical trials in patients with leukemia and lymphoma. Additionally, this review will highlight limitations in current strategies, discuss efforts in toxicity mitigation, and outline future directions for investigation.

Recent findings

CD19 targeted CAR-T-cell therapy (CD19-CAR) is highly effective in patients with relapsed/refractory (r/r) B-cell hematologic malignancies. However, multiple challenges have arisen, particularly life-threatening adverse events, such as cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. Despite these challenges, recent CD19-CAR trials, including two randomized studies, have demonstrated both impressive initial results along with durable responses. Combined with results emerging from 'real-world' experience, the efficacy of CAR-T-cells is high, propelling CAR-T-cells studies targeting alternate B-cell antigens [e.g. CD20, CD22 and CD269 (BCMA)] and other targets for hematologic malignancies, along with solid and CNS tumors.

Summary

Given the benefit for CD19-CAR, determining the appropriate place in utilization for both an individual patient's treatment course and more broadly in the generalized treatment paradigm is critically needed. We discuss the most recent trials exploring this topic and future directions in the field.

SUBMITTER: Schroeder BA

PROVIDER: S-EPMC9354650 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Publications

Clinical trials for chimeric antigen receptor T-cell therapy: lessons learned and future directions.

Schroeder Brett A BA Jess Jennifer J Sankaran Hari H Shah Nirali N NN

Current opinion in hematology 20220701 4

<h4>Purpose of review</h4>The purpose of this review is to summarize the status and utilization of chimeric antigen receptor T-cell (CAR-T) therapy based on the most recent clinical trials in patients with leukemia and lymphoma. Additionally, this review will highlight limitations in current strategies, discuss efforts in toxicity mitigation, and outline future directions for investigation.<h4>Recent findings</h4>CD19 targeted CAR-T-cell therapy (CD19-CAR) is highly effective in patients with re ...[more]

PMID: 35787551

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Dataset Information

Clinical trials for chimeric antigen receptor T-cell therapy: lessons learned and future directions.

Purpose of review

Recent findings

Summary

Publications

Clinical trials for chimeric antigen receptor T-cell therapy: lessons learned and future directions.

Similar Datasets

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