Phenotypic, trophic, and regenerative properties of mesenchymal stem cells from different osseous tissues.

ABSTRACT: Mesenchymal stem cells (MSCs) have broad-based therapeutic potential in regenerative medicine. However, a major barrier to their clinical utility is that MSCs from different tissues are highly variable in their regenerative properties. In this study, we defined the molecular and phenotypic identities of different MSC populations from different osseous tissue sites of different patients and, additionally, determined their respective regenerative properties. MSCs from 6 patients were isolated from either bone marrow of the iliac crest (BMSCs) or alveolar bone tissue (aBMSCs), and flow cytometry revealed that regardless of the tissue source, MSC immunotypes had the same expression of MSC markers CD73, CD90, and CD105. However, transcriptomic analyses revealed 589 genes differentially expresse

SUBMITTER: Zou D 

PROVIDER: S-EPMC9354673 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature