Ancestral dietary change alters the development of Drosophila larvae through MAPK signalling.

ABSTRACT: Studies in a broad range of animal species have revealed phenotypes that are caused by ancestral life experiences, including stress and diet. Ancestral dietary macronutrient composition and quantity (over- and under-nutrition) have been shown to alter descendent growth, metabolism and behaviour. Molecules have been identified in gametes that are changed by ancestral diet and are required for transgenerational effects. However, there is less understanding of the developmental pathways altered by inherited molecules during the period between fertilization and adulthood. To investigate this non-genetic inheritance, we exposed great grand-parental and grand-parental generations to defined protein to carbohydrate (P:C) dietary ratios. Descendent developmental timing was consistently faster in t

SUBMITTER: Towarnicki SG 

PROVIDER: S-EPMC9354765 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature