New integrated weaning indices from mechanical ventilation: A derivation-validation observational multicenter study.

ABSTRACT:

Background

To develop ten new integrated weaning indices that can predict the weaning outcome better than the traditional indices.

Methods

This retrospective-prospective derivation-validation observational multicenter clinical trial (Clinical Trial.Gov, NCT01779297), was conducted on 1,175 adult patients admitted at 9 academic affiliated intensive care units (ICUs; 4 surgical and 5 medical), from Jan 2013 to Dec 2018. All patients, intubated and mechanically ventilated for at least 24 h and ready for weaning were enrolled. The study had two phases: at first, the threshold values of each index that best discriminate between a successful and an unsuccessful weaning outcome was determined among 208 patients in the derivation group. In the second phase, the predictive performanc

SUBMITTER: Vahedian-Azimi A 

PROVIDER: S-EPMC9354807 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature