RAID: Regression Analysis-Based Inductive DNA Microarray for Precise Read-Across.

ABSTRACT: Chemical structure-based read-across represents a promising method for chemical toxicity evaluation without the need for animal testing; however, a chemical structure is not necessarily related to toxicity. Therefore, in vitro studies were often used for read-across reliability refinement; however, their external validity has been hindered by the gap between in vitro and in vivo conditions. Thus, we developed a virtual DNA microarray, regression analysis-based inductive DNA microarray (RAID), which quantitatively predicts in vivo gene expression profiles based on the chemical structure and/or in vitro transcriptome data. For each gene, elastic-net models were constructed using chemical descriptors and in vitro transcriptome data to predict in vi

SUBMITTER: Amano Y 

PROVIDER: S-EPMC9354856 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature