Diagnostic value of striatal ¹⁸F-FP-DTBZ PET in Parkinson's disease.

ABSTRACT:

Background

¹⁸F-FP-DTBZ has been proven as a biomarker for quantifying the concentration of presynaptic vesicular monoamine transporter 2 (VMAT2). However, its clinical application is still limited.

Objectives

To evaluate the difference in dopaminergic integrity between patients with Parkinson's disease (PD) and healthy controls (HC) using ¹⁸F-FP-DTBZ PET in vivo and to determine the diagnostic value of standardized uptake value ratios (SUVRs) using the Receiver Operating Characteristic (ROC) curve.

Methods

A total of 34 PD and 31 HC participants were enrolled in the PET/MR derivation cohort, while 89 PD and 18 HC participants were recruited in the PET/CT validation cohort. The Hoehn-Yahr Scale and the third part of the MDS-Unified Parkinso

SUBMITTER: Liu XL 

PROVIDER: S-EPMC9355024 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature