Longitudinal electrophysiological changes after mesenchymal stem cell transplantation in a spinal cord injury rat model.

ABSTRACT: Transcranial electrically stimulated motor-evoked potentials (tcMEPs) are widely used to evaluate motor function in humans and animals. However, the relationship between tcMEPs and the recovery of paralysis remains unclear. We previously reported that transplantation of mesenchymal stem cells to a spinal cord injury (SCI) rat model resulted in various degrees of recovery from paraplegia. As a continuation of this work, in the present study, we aimed to establish the longitudinal electrophysiological changes in this SCI rat model after mesenchymal stem cell transplantation. SCI rats were established using the weight-drop method. The model rats were transvenously transplanted with two types of mesenchymal stem cells (MSCs), one derived from rat cranial bones and the other from the bone marro

SUBMITTER: Maeda Y 

PROVIDER: S-EPMC9355172 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature