Development and validation of a new prognostic index for mortality risk in multimorbid adults.

ABSTRACT:

Context

Multimorbidity is highly prevalent among older adults and associated with a high mortality. Prediction of mortality in multimorbid people would be clinically useful but there is no mortality risk index designed for this population. Our objective was therefore to develop and internally validate a 1-year mortality prognostic index for older multimorbid adults.

Methods

We analysed data of the OPERAM cohort study in Bern, Switzerland, including 822 adults aged 70 years or more with multimorbidity (3 or more chronic medical conditions) and polypharmacy (use of 5 drugs or more for >30 days). Time to all-cause mortality was assessed up to 1 year of follow-up. We performed a parametric Weibull regression model with backward stepwise selection to identify mortality risk predi

SUBMITTER: Gastens V 

PROVIDER: S-EPMC9355209 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature