Circadian transcription factor NPAS2 and the NAD⁺ -dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward.

ABSTRACT: Substance use disorders are associated with disruptions to both circadian rhythms and cellular metabolic state. At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD⁺ )-dependent deacetylase, sirtuin 1 (SIRT1). In the nucleus accumbens (NAc), a region important for reward, both SIRT1 and the circadian transcription factor neuronal PAS domain protein 2 (NPAS2) are highly enriched, and both are regulated by the metabolic cofactor NAD⁺ . Substances of abuse, like cocaine, greatly disrupt cellular metabolism and promote oxidative stress; however, their effects on NAD⁺ in the brain remain unclear. Interestingly, cocaine also induces NAc express

SUBMITTER: Becker-Krail DD 

PROVIDER: S-EPMC9355311 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature