LncRNA-GM targets Foxo1 to promote T cell-mediated autoimmunity.

ABSTRACT: RNA-RBP interaction is important in immune regulation and implicated in various immune disorders. The differentiation of proinflammatory T cell subset T_H17 and its balance with regulatory T cell (T_reg) generation is closely related to autoimmune pathogenesis. The roles of RNA-RBP interaction in regulation of T_H17/T_reg differentiation and autoinflammation remain in need of further investigation. Here we report that lncRNA-GM polarizes T_H17 differentiation but inhibits iT_reg differentiation by reducing activity of Foxo1, a transcriptional factor that is important in inhibiting T_H17 differentiation but promoting T_reg generation. lncRNA-GM-deficient mice were protected from experimental autoimmune en

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9355365 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature