Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An in vitro Study.

ABSTRACT: Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE). Ex-vivo studies in mTLE hippocampal surgical specimens have shown increased mGluR5 immunoreactivity, while in vivo whole brain imaging using positron emission tomography (PET) demonstrated reduced hippocampal mGluR5 availability. To further understand mGluR5 abnormalities in mTLE, we performed a saturation autoradiography study with [³H]ABP688 (a negative mGluR5 allosteric modulator). We aimed to evaluate receptor density (B_max) and dissociation constants (K_D) in hippocampal mTLE surgical specimens and in non-epilepsy hippocampi from necropsy controls. mTL

SUBMITTER: Zimmermann M 

PROVIDER: S-EPMC9355376 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature