The Effect of Sleep Restriction, With or Without Exercise, on Skeletal Muscle Transcriptomic Profiles in Healthy Young Males.

ABSTRACT:

Background

Inadequate sleep is associated with many detrimental health effects, including increased risk of developing insulin resistance and type 2 diabetes. These effects have been associated with changes to the skeletal muscle transcriptome, although this has not been characterised in response to a period of sleep restriction. Exercise induces a beneficial transcriptional response within skeletal muscle that may counteract some of the negative effects associated with sleep restriction. We hypothesised that sleep restriction would down-regulate transcriptional pathways associated with glucose metabolism, but that performing exercise would mitigate these effects.

Methods

20 healthy young males were allocated to one of three experimental groups: a Normal Sleep (NS) group (8

SUBMITTER: Lin W 

PROVIDER: S-EPMC9355502 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature