NKCC1 and KCC2: Structural insights into phospho-regulation.

ABSTRACT: Inhibitory neurotransmission plays a fundamental role in the central nervous system, with about 30-50% of synaptic connections being inhibitory. The action of both inhibitory neurotransmitter, gamma-aminobutyric-acid (GABA) and glycine, mainly relies on the intracellular Cl^- concentration in neurons. This is set by the interplay of the cation chloride cotransporters NKCC1 (Na⁺, K⁺, Cl^- cotransporter), a main Cl^- uptake transporter, and KCC2 (K⁺, Cl^- cotransporter), the principle Cl^- extruder in neurons. Accordingly, their dysfunction is associated with severe neurological, psychiatric, and neurodegenerative disorders. This has triggered great interest in understanding their regulation, with a strong foc

SUBMITTER: Hartmann AM 

PROVIDER: S-EPMC9355526 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature