The prognostic value and biological significance of gap junction beta protein 2 (GJB2 or Cx26) in cervical cancer.

ABSTRACT:

Objective

To evaluate the prognostic value and explore the biological significance of gap junction protein beta 2 (GJB2 or Cx26) in cervical cancer (CC).

Methods

We first compared GJB2 expression between CC and normal tissues using public databases and immunohistochemistry (IHC). Based on The Cancer Genome Atlas data (TCGA cohort, n = 304) and tissue microarray samples (OBC cohort, n = 111), we explored the prognostic value of GJB2 for CC patients using bioinformatics analysis and IHC scoring. To explore the biological significance of GJB2, Gene set enrichment analysis (GSEA) and Gene Ontology (GO) were performed. The impact of GJB2 on the immune microenvironment was analyzed by CIBERSORTx and ESTIMATE algorithms. We finally investigated the relationship between GJB2 and dru

SUBMITTER: Meng S 

PROVIDER: S-EPMC9355537 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature