Evaluating the Potential of Polygenic Risk Score to Improve Colorectal Cancer Screening.

ABSTRACT:

Background

Colorectal cancer has high incidence and associated mortality worldwide. Screening programs are recommended for men and women over 50. Intermediate screens such as fecal immunochemical testing (FIT) select patients for colonoscopy with suboptimal sensitivity. Additional biomarkers could improve the current scenario.

Methods

We included 2,893 individuals with a positive FIT test. They were classified as cases when a high-risk lesion for colorectal cancer was detected after colonoscopy, whereas the control group comprised individuals with low-risk or no lesions. 65 colorectal cancer risk genetic variants were genotyped. Polygenic risk score (PRS) and additive models for risk prediction incorporating sex, age, FIT value, and PRS were generated.

Results

Risk sc

SUBMITTER: Arnau-Collell C 

PROVIDER: S-EPMC9355543 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature