Ontology highlight
ABSTRACT:
SUBMITTER: Lang K
PROVIDER: S-EPMC9355562 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Lang Konrad K Milosavljevic Julian J Heinkele Helena H Chen Mengmeng M Gerstner Lea L Spitz Dominik D Kayser Severine S Helmstädter Martin M Walz Gerd G Köttgen Michael M Spracklen Andrew A Poulton John J Hermle Tobias T
eLife 20220725
The kidneys generate about 180 l of primary urine per day by filtration of plasma. An essential part of the filtration barrier is the slit diaphragm, a multiprotein complex containing nephrin as major component. Filter dysfunction typically manifests with proteinuria and mutations in endocytosis regulating genes were discovered as causes of proteinuria. However, it is unclear how endocytosis regulates the slit diaphragm and how the filtration barrier is maintained without either protein leakage ...[more]