Statistical framework to support the epidemiological interpretation of SARS-CoV-2 concentration in municipal wastewater.

ABSTRACT: The ribonucleic acid (RNA) of the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is detectable in municipal wastewater as infected individuals can shed the virus in their feces. Viral concentration in wastewater can inform the severity of the COVID-19 pandemic but observations can be noisy and sparse and hence hamper the epidemiological interpretation. Motivated by a Canadian nationwide wastewater surveillance data set, unlike previous studies, we propose a novel Bayesian statistical framework based on the theories of functional data analysis to tackle the challenges embedded in the longitudinal wastewater monitoring data. By employing this framework to analyze the large-scale data set from the nationwide wastewater surveillance program covering 15 sampling sites across Canad

SUBMITTER: Dai X 

PROVIDER: S-EPMC9355971 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature