Ontology highlight
ABSTRACT:
SUBMITTER: Van Nyen T
PROVIDER: S-EPMC9355973 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Van Nyen Tom T Planque Mélanie M van Wagensveld Lilian L Duarte Joao A G JAG Zaal Esther A EA Talebi Ali A Rossi Matteo M Körner Pierre-René PR Rizzotto Lara L Moens Stijn S De Wispelaere Wout W Baiden-Amissah Regina E M REM Sonke Gabe S GS Horlings Hugo M HM Eelen Guy G Berardi Emanuele E Swinnen Johannes V JV Berkers Celia R CR Carmeliet Peter P Lambrechts Diether D Davidson Ben B Agami Reuven R Fendt Sarah-Maria SM Annibali Daniela D Amant Frédéric F
Nature communications 20220805 1
Resistance to platinum-based chemotherapy represents a major clinical challenge for many tumors, including epithelial ovarian cancer. Patients often experience several response-relapse events, until tumors become resistant and life expectancy drops to 12-15 months. Despite improved knowledge of the molecular determinants of platinum resistance, the lack of clinical applicability limits exploitation of many potential targets, leaving patients with limited options. Serine biosynthesis has been lin ...[more]