Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC9356001 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Liu Yize Y Qiu Guanzhen G Luo Yinzhou Y Li Shanshan S Xu Yeqiu Y Zhang Yuanzhuang Y Hu Jiayuan J Li Peifeng P Pan Hai H Wang Yong Y
Experimental & molecular medicine 20220725 7
As the most prevalent bone tumor in children and adolescents, the pathogenesis and metastasis of osteosarcoma (OS) remain largely unclear. Here, we investigated the expression and function of a novel circular RNA (circRNA), circROCK1-E3/E4, which is back-spliced from exons 3 and 4 of Rho-associated coiled-coil containing protein kinase 1 (ROCK1) in OS. We found that circROCK1-E3/E4, regulated by the well-known RNA-binding protein quaking (QKI), was downregulated in OS and correlated with unfavor ...[more]