The permeation of potassium ions through the lipid scrambling path of the membrane protein nhTMEM16.

ABSTRACT: The TMEM16 family of transmembrane proteins includes Ca²⁺-activated phospholipid scramblases (PLS) that can also function as non-selective ion channels. Extensive structural and functional studies have established that a membrane-exposed hydrophilic groove in TMEM16 PLS can serve as a translocation pathway for lipids. However, it is still unclear how the TMEM16 PLS conduct ions. A "protein-delimited pore" model suggests that ions are translocated through a narrow opening of the groove region, which is not sufficiently wide to allow lipid movement, whereas a "proteolipidic pore" model envisions ions and lipids translocating through an open conformation of the groove. We investigated the dynamic path of potassium ion (K⁺) translocation that occurs when an open groove st

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9356224 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature