Sex-specific effects of maternal dietary carbohydrate quality on fetal development and offspring metabolic phenotype in mice.

ABSTRACT:

Objectives

In utero glycemia is an important determinant of fetal growth. Women with gestational diabetes are more likely to deliver large-for-gestational age babies that are at increased risk for obesity. The maternal nutritional state modulates the development of offspring biological systems during the critical periods of gestation and lactation. Carbohydrate typically contributes most of the dietary energy, however, there are very few mechanistic studies investigating the effects of maternal dietary carbohydrate quality on fetal and offspring outcomes. Therefore, we sought to investigate the direct effects of maternal carbohydrate quality on sex-specific offspring metabolic programming.

Methods

Female C57BL/6 mice were fed one of five isocaloric diets: four high-su

SUBMITTER: Campbell GJ 

PROVIDER: S-EPMC9356227 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature