Differential trajectories of tobacco smoking in people at ultra-high risk for psychosis: Associations with clinical outcomes.

ABSTRACT:

Objective

People at ultra-high risk (UHR) for psychosis have a high prevalence of tobacco smoking, and rates are even higher among the subgroup that later develop a psychotic disorder. However, the longitudinal relationship between the course of tobacco smoking and clinical outcomes in UHR subjects is unknown.

Methods

We investigated associations between tobacco smoking and clinical outcomes in a prospective study of UHR individuals (n = 324). Latent class mixed model analyses were used to identify trajectories of smoking severity. Mixed effects models were applied to investigate associations between smoking trajectory class and the course of attenuated psychotic symptoms (APS) and affective symptoms, as assessed using the CAARMS.

Results

We identified four dif

SUBMITTER: Schirmbeck F 

PROVIDER: S-EPMC9356251 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature