Lymphocyte-sparing pelvic radiotherapy for prostate cancer: An in-silico study.

ABSTRACT:

Background and purpose

Evidence regarding radiation-induced lymphopenia and its negative impact on oncological outcome is incrementing. Therefore, the aim of this study is to evaluate the feasibility of lymphocyte-rich organs at risk (LOAR) sparing in pelvic irradiation for localized prostate cancer and to estimate its impact on the effective dose to circulating immune cells (EDIC).

Materials and methods

Twenty patients with pelvic nodal and prostate or prostate bed irradiation were included. The following bone marrow (BM) structures were delineated as LOARs using semi-automatic segmentation: lumbosacral spine (Ls-BM), ilium (Il-BM), lower pelvis (Lp-BM), and the combined whole-pelvis (Wp-BM). Twenty new lymphocyte sparing treatment plans (LS plans) were calculated, optimizi

SUBMITTER: Bare M 

PROVIDER: S-EPMC9356260 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature