Phylogenetic lineages of tuberculosis isolates and their association with patient demographics in Tanzania.

ABSTRACT:

Background

Mycobacterium tuberculosis presents several lineages each with distinct characteristics of evolutionary status, transmissibility, drug resistance, host interaction, latency, and vaccine efficacy. Whole genome sequencing (WGS) has emerged as a new diagnostic tool to reliably inform the occurrence of phylogenetic lineages of Mycobacterium tuberculosis and examine their relationship with patient demographic characteristics and multidrug-resistance development.

Methods

191 Mycobacterium tuberculosis isolates obtained from a 2017/2018 Tanzanian drug resistance survey were sequenced on the Illumina Miseq platform at Supranational Tuberculosis Reference Laboratory in Uganda. Obtained fast-q files were imported into tools for resistance profiling and lineage inference (Kv

SUBMITTER: Mutayoba BK 

PROVIDER: S-EPMC9356438 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature