The significance of the fusion partner gene genomic neighborhood analysis in translocation-defined tumors.

ABSTRACT:

Introduction

This study presents a novel molecular parameter potentially co-defining tumor biology-the total tumor suppressor gene (TSG) count at chromosomal loci harboring genes rearranged in fusion-defined tumors. It belongs to the family of molecular parameters created using a black-box approach.

Method

It is based on a public curated Texas TSG database. Its data are regrouped based on individual genes loci using another public database (Genecards). The total TSG count for NTRK (NTRK1; OMIM: 191315; NTRK2; OMIM: 600456; NTRK3; OMIM: 191316), NRG1 (OMIM: 142445), and RET (OMIM: 164761) rearranged tumors in patients treated with a theranostic approach is calculated using the results of recently published studies.

Results

Altogether 138 loci containing at least three

SUBMITTER: Mosaieby E 

PROVIDER: S-EPMC9356546 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature