Differential proteomic analysis of mouse cerebrums with high-fat diet (HFD)-induced hyperlipidemia.

ABSTRACT: Hyperlipidemia is a chronic disease characterized by elevated blood cholesterol and triglycerides and there is accumulated evidence that the disease might affect brain functions. Here we report on a proteomic analysis of the brain proteins in hyperlipidemic mice. Hyperlipidemia was successfully induced in mice by a 20 week high-fat diet (HFD) feeding (model group). A control group with a normal diet and a treatment group with HFD-fed mice treated with a lipid-lowering drug simvastatin (SIM) were established accordingly. The proteins were extracted from the left and right cerebrum hemispheres of the mice in the three groups and subjected to shotgun proteomic analysis. A total of 4,422 proteins were detected in at least half of the samples, among which 324 proteins showed significant differe

SUBMITTER: Chen C 

PROVIDER: S-EPMC9356585 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature