Uncovering Signals of Positive Selection in Peruvian Populations from Three Ecological Regions.

ABSTRACT: Peru hosts extremely diverse ecosystems which can be broadly classified into the following three major ecoregions: the Pacific desert coast, the Andean highlands, and the Amazon rainforest. Since its initial peopling approximately 12,000 years ago, the populations inhabiting such ecoregions might have differentially adapted to their contrasting environmental pressures. Previous studies have described several candidate genes underlying adaptation to hypobaric hypoxia among Andean highlanders. However, the adaptive genetic diversity of coastal and rainforest populations has been less studied. Here, we gathered genome-wide single-nucleotide polymorphism-array data from 286 Peruvians living across the three ecoregions and analyzed signals of recent positive selection through population differe

SUBMITTER: Caro-Consuegra R 

PROVIDER: S-EPMC9356722 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature