Leptin mutation and mycobacterial infection lead non-synergistically to a similar metabolic syndrome.

ABSTRACT:

Introduction

The leptin signaling pathway plays an important role as a key regulator of glucose homeostasis, metabolism control and systemic inflammatory responses. However, the metabolic effects of leptin on infectious diseases, for example tuberculosis (TB), are still little known.

Objectives

In this study, we aim to investigate the role of leptin on metabolism in the absence and presence of mycobacterial infection in zebrafish larvae and mice.

Methods

Metabolites in entire zebrafish larvae and the blood of mice were studied using high-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and mass spectrometry, respectively. For transcriptome studies of zebrafish larvae, deep RNA sequencing was used.

Results

The results show tha

SUBMITTER: Ding Y 

PROVIDER: S-EPMC9356939 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature