Infant Visual Brain Development and Inherited Genetic Liability in Autism.

ABSTRACT:

Objective

Autism spectrum disorder (ASD) is heritable, and younger siblings of ASD probands are at higher likelihood of developing ASD themselves. Prospective MRI studies of siblings report that atypical brain development precedes ASD diagnosis, although the link between brain maturation and genetic factors is unclear. Given that familial recurrence of ASD is predicted by higher levels of ASD traits in the proband, the authors investigated associations between proband ASD traits and brain development among younger siblings.

Methods

In a sample of 384 proband-sibling pairs (89 pairs concordant for ASD), the authors examined associations between proband ASD traits and sibling brain development at 6, 12, and 24 months in key MRI phenotypes: total cerebral volume, cortical surfa

SUBMITTER: Girault JB 

PROVIDER: S-EPMC9356977 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature