Notch, Numb and Numb-like responses to exercise-induced muscle damage in human skeletal muscle.

ABSTRACT:

New findings

What is the central question of this study? Do Notch, Numb and Numb-like expression change in human skeletal muscle after exercise-induced muscle damage? What are the main finding and its importance? Notch gene expression trends toward an increase in response to an acute bout of exercise-induced muscle damage, while Numb and Numb-like expression does not change. These results suggest that human skeletal muscle response to exercise-induced muscle damage is dynamic and may differ from Drosophila and rodent models. Furthermore, the timing of muscle biopsies, training status and muscle damage protocols should be considered.

Abstract

This investigation examined changes in the gene and protein expression of Notch, Numb and Numb-like (Numbl) in human skeletal muscle af

SUBMITTER: Bubak MP 

PROVIDER: S-EPMC9356995 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature