Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice.

ABSTRACT: Circadian clocks in the mammalian retina regulate a diverse range of retinal functions that allow the retina to adapt to the light-dark cycle. Emerging evidence suggests a link between the circadian clock and retinopathies though the causality has not been established. Here we report that clock genes are expressed in the mouse embryonic retina, and the embryonic retina requires light cues to maintain robust circadian expression of the core clock gene, Bmal1. Deletion of Bmal1 and Per2 from the retinal neurons results in retinal angiogenic defects similar to when animals are maintained under constant light conditions. Using two different models to assess pathological neovascularization, we show that neuronal Bmal1 deletion reduces neovascularization with reduced vascular leakage, suggesting

SUBMITTER: Jidigam VK 

PROVIDER: S-EPMC9357084 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature