Muscle oxygenation during normoxic and hypoxic cycling exercise in humans with high-affinity haemoglobin.

ABSTRACT:

New findings

What is the central question of this study? Do humans with high-affinity haemoglobin (HAH) demonstrate attenuated skeletal muscle deoxygenation during normoxic and hypoxic exercise? What is the main finding and its importance? Examination of near-infrared spectroscopy-derived muscle oxygenation profiles suggests that fractional oxygen extraction is blunted during hypoxic exercise in humans with HAH compared with control subjects. However, muscle tissue oxygen saturation levels were higher in humans with HAH during exercise in normoxia compared with control subjects. These alterations in fractional oxygen extraction in humans with HAH might influence blood flow regulation and exercise capacity during hypoxia.

Abstract

Recently, researchers in our laboratory have

SUBMITTER: Webb KL 

PROVIDER: S-EPMC9357130 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature