Restoration of Cardiomyogenesis in Aged Mouse Hearts by Voluntary Exercise.

ABSTRACT:

Background

The human heart has limited capacity to generate new cardiomyocytes and this capacity declines with age. Because loss of cardiomyocytes may contribute to heart failure, it is crucial to explore stimuli of endogenous cardiac regeneration to favorably shift the balance between loss of cardiomyocytes and the birth of new cardiomyocytes in the aged heart. We have previously shown that cardiomyogenesis can be activated by exercise in the young adult mouse heart. Whether exercise also induces cardiomyogenesis in aged hearts, however, is still unknown. Here, we aim to investigate the effect of exercise on the generation of new cardiomyocytes in the aged heart.

Methods

Aged (20-month-old) mice were subjected to an 8-week voluntary running protocol, and age-matched sedenta

SUBMITTER: Lerchenmuller C 

PROVIDER: S-EPMC9357140 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature