Developmental Pathways Are Epigenetically Reprogrammed during Lung Cancer Brain Metastasis.

ABSTRACT: Non-small cell lung cancer (NSCLC) is one of the most commonly diagnosed and deadliest cancers worldwide, with roughly half of all patients initially presenting with both primary and metastatic disease. While the major events in the metastatic cascade have been identified, a mechanistic understanding of how NSCLC routinely and successfully colonizes the brain is largely unknown. Recent studies have begun demonstrating the role of epigenetic misregulation during tumorigenesis and metastasis, including widespread changes in DNA methylation and histone modifications. To better understand the role of altered DNA methylation in NSCLC metastasis to the brain, we measured DNA methylation during disease progression for 12 patients, globally profiling the methylation status of normal lung, primary

SUBMITTER: Karlow JA 

PROVIDER: S-EPMC9357144 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature