Rapid and flexible online desalting using Nafion-coated melamine sponge for mass spectrometry analysis.

ABSTRACT:

Rationale

The performance of mass spectrometry (MS) analysis is often affected by the presence of salt ions. To achieve optimal MS detection results, desalting is necessary for samples with high salt concentrations. We report a rapid, low-cost and flexible online desalting method using Nafion-coated sponge. This method is easy to perform and can be implemented to a wide range of customized fluidic systems.

Methods

Nafion-coated melamine sponge was fabricated by soaking a glass tube containing a melamine sponge in Nafion solution and then drying overnight. The online desalting workflow is comprised of three major parts: (1) Syringe pump, which provides a continuous flow for the online fluid system; (2) Nafion sponge in a glass tube, where the online desalting of sample soluti

SUBMITTER: Li C 

PROVIDER: S-EPMC9357145 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature