Improved T-cell Immunity Following Neoadjuvant Chemotherapy in Ovarian Cancer.

ABSTRACT:

Purpose

Although local tissue-based immune responses are critical for elucidating direct tumor-immune cell interactions, peripheral immune responses are increasingly recognized as occupying an important role in anticancer immunity. We evaluated serial blood samples from patients with advanced epithelial ovarian cancer (EOC) undergoing standard-of-care neoadjuvant carboplatin and paclitaxel chemotherapy (including dexamethasone for prophylaxis of paclitaxel-associated hypersensitivity reactions) to characterize the evolution of the peripheral immune cell function and composition across the course of therapy.

Experimental design

Serial blood samples from 10 patients with advanced high-grade serous ovarian cancer treated with neoadjuvant chemotherapy (NACT) were collected befor

SUBMITTER: Liu M 

PROVIDER: S-EPMC9357177 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature