Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.

ABSTRACT: Acute myeloid leukemia (AML) is driven by mutations that occur in numerous combinations. A better understanding of how mutations interact with one another to cause disease is critical to developing targeted therapies. Approximately 50% of patients that harbor a common mutation in NPM1 (NPM1cA) also have a mutation in the cohesin complex. As cohesin and Npm1 are known to regulate gene expression, we sought to determine how cohesin mutation alters the transcriptome in the context of NPM1cA. We utilized inducible Npm1^cAflox/+ and core cohesin subunit Smc3^flox/+ mice to examine AML development. While Npm1^cA/+;Smc3^Δ/+ mice developed AML with a similar latency and penetrance as Npm1^cA/+ mice, RNA-seq suggests that the Npm1^cA/+; Sm

SUBMITTER: Meyer AE 

PROVIDER: S-EPMC9357218 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature